The Biosynthesis and Biomimetic Synthesis of Merochlorins A and B

Henry P. Pepper; Jonathan H. George

doi:10.1055/s-0035-1560635

Synlett, Inhaltsverzeichnis

Synlett 2015; 26(18): 2485-2490
DOI: 10.1055/s-0035-1560635

synpacts

The Biosynthesis and Biomimetic Synthesis of Merochlorins A and B

Autor*innen

Henry P. Pepper

Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia eMail: jonathan.george@adelaide.edu.au
Jonathan H. George*

Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia eMail: jonathan.george@adelaide.edu.au

Abstract

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Abstract

The interplay between biosynthetic studies and biomimetic synthesis is discussed in the context of the merochlorin family of marine natural products. Total syntheses of merochlorin A by our group and merochlorin B by the Trauner group are presented alongside the biosynthetic studies of Moore and co-workers. The common theme is the generation of complex polycyclic ring systems by oxidative dearomatization–cyclization cascade reactions.

Key words

biomimetic synthesis - cascade reactions - natural products - meroterpenoids - oxidative dearomatization

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Referenzen

References

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